CYP3A enzymes, a major subset of the cytochrome P450 superfamily, play a central role in the metabolism of approximately half of all clinically used drugs. Interindividual variability in CYP3A ...
Anti-oxidant response element (ARE) and nuclear factors including Nrf2 and small Maf (MafG and MafK) proteins are known to regulate expression and induction of detoxifying enzyme genes including ...
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