Researchers show that loss of the SPRTN enzyme lets DNA–protein crosslinks accumulate, leak DNA into the cytoplasm, activate ...

Although DNA is tightly packed and protected within the cell nucleus, it is constantly threatened by damage from normal ...

Genome instability can cause numerous diseases. Cells have effective DNA repair mechanisms at their disposal. A research team has now gained new insights into the DNA damage response. Whenever cells ...

DNA is often described as the instruction manual for building the fundamental components of life. Proteins are helpers that ...

Although DNA is tightly packed and safeguarded within the cell nucleus, it remains continually at risk of damage from normal ...

A previously unknown type of DNA damage in the mitochondria, the tiny power plants inside our cells, could shed light on how our bodies sense and respond to stress. The findings of the UC ...

While most known types of DNA damage are fixed by our cells' in-house DNA repair mechanisms, some forms of DNA damage evade repair and can persist for many years, new research shows. This means that ...

Objectives Understanding the molecular changes in the preclinical synovium is crucial for identifying factors that drive ...

If severe DNA damage is not repaired, the consequences for the health of cells and tissues are dramatic. A study led by researchers at Goethe ...